Challenges that lie ahead

Systemic cancer therapy: achievements and challenges that lie ahead

In the last half of the century, advances in the systemic therapy of cancer, including chemotherapy, hormonal therapy, targeted therapy, and immunotherapy have been responsible for improvements in cancer related mortality in developed countries even as the population continues to age. Although such advancements have yet to benefit all cancer types, systemic therapies have led to an improvement ...

Nanoparticle contrast agents for CT : their potential and the challenges that lie ahead

The number of reports of nanoparticle CT contrast agents has been growing swiftly over the past 5 years. These nanoparticles can be applied to produce long-lived CT contrast in the blood vessels and to perform targeted imaging, and can be used in conjunction with a new CT technique – multicolor CT. Such innovations offer the promise of new applications and diagnoses that can be performed with C...

The Challenges Ahead

Middleware Challenges Ahead

24 Computer Middleware Challenges Ahead I n the first attempts to define comprehensive software platforms for distributed applications 25 years ago, researchers created basic middleware elements such as remote procedure call, file service, and directory service based on dramatic advances in hardware technology and fast networking and workstation systems. Today, the scope of middleware is broade...

Ten big challenges ahead

1. Can We Cure AIDS? This is an intense area of investigation at the current time with much focus on the activation of latently infected cells within reservoirs by such agents as histone deacetylase inhibitors. However, there is concern about some of these approaches due to considerations of possible long-term toxicities involving the activating agents as well as questions about whether it will...